|
KMID : 0829320100130010014
|
|
Korean Journal of Clinical Microbiology
2010 Volume.13 No. 1 p.14 ~ p.18
|
|
|
Investigation of Positive Streptococcus pneumoniae Urinary Antigen Test Results in a Korean University Hospital
|
|
Kim In-Suk
Jung Hyun-Ju
Koh Eun-Ha
Kim Sun-Joo
Maeng Kook-Young
|
|
|
Abstract
|
|
|
Background: The Streptococcus pneumoniae urinary antigen test (SPUAT) (Binax Now, USA) was developed for detecting polysaccharide C in urine samples for rapid diagnosis of pneumococcal pneumonia, the most common cause of community-acquired pneumonia (CAP). To validate positive results of these tests, we retrospectively investigated all positive results obtained from the emergency room of a Korean university hospital among patients with suspected CAP.
Methods: One hundred twenty-three positive SPUAT results were abstracted and analyzed from the authors’ laboratory information system among the SPUAT results performed from 1,143 pneumonic patients admitted from the emergency room of a university hospital between 2007 and 2008. Medical records, including conventional microbiologic analysis results, were reviewed in detail for all positive test results.
Results: Among 123 patients with the positive SPUAT results, 24 patients were excluded due to hospitalization history during the preceding month. Nine of 99 patients (9.1%) with suspected CAP had confirmed pneumococcal pneumonia upon conventional sputum or blood culture. Thirty-five positive results (35.4%) showed other microorganisms upon conventional methods, which might be due to possible cross-reactivity. Among those, 23 positive results were considered bacterial pneumonic agents, and 12 positive results were regarded as urinary tract infection strains or contaminating agents. Fifty-five positive SPUAT results (55.6%) showed negative conventional microbiologic growth, and some positive SPUAT results might be caused by true pneumococcal infection although without cultural evidence.
Conclusion: Our retrospective study demonstrated that a positive SPUAT result typically does not agree well with conventional culture methods, suggesting that the value of a positive SPUAT result in etiology determination may be limited under practical conditions in a university hospital.
|
|
|
KEYWORD
|
|
|
Streptococcus pneumoniae, Bacterial antigens, Urinary antigen test, Cross-reactivity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|